对于末期病患者在移植可及性方面的非描述性合规性标签的挑战
Benjamin Peticca1, Tomas M Prudencio1, Samuel G Robinson1
1Department of Surgery, Lewis Katz School of Medicine at Temple University Hospital, Philadelphia, PA 19140, United States.
World journal of nephrology
|April 10, 2024
概括
使用"不合规"等术语不公平地责怪患者,并限制对器官移植的准入. 这种语言忽视了健康的社会决定因素,并导致了移植机会的减少,特别是对于少数群体.
科学领域:
- 医学伦理学医学伦理学
- 移植医学是一种移植医学.
- 卫生公平性健康公平性
背景情况:
- 临床语言,如"不合规"或"不坚持",不公平地将责任归咎于患者.
- 这些条款可能会导致等待列表失活,并减少获得挽救生命的器官移植的机会.
- 现有的健康社会决定因素和保险覆盖不足导致患者难以遵守护理方案.
研究的目的:
- 分析非描述性临床语言对患者护理和移植机会的影响.
- 突出"不合规"等术语如何在器官分配中延续偏见和主观性.
- 倡导在医疗记录和临床决策中使用更准确和以患者为中心的语言.
主要方法:
- 在移植中使用的临床术语的定性分析.
- 审查器官分配政策及其依赖患者执法标签的情况.
- 检查健康的社会决定因素对患者结果和获得护理的影响.
主要成果:
- 像"不合规"这样的非描述性标签是主观的,无法捕捉影响患者遵守的复杂情况.
- 这些标签导致了获得器官移植的重大障碍,不成比例地影响了弱势群体.
- 医疗保险覆盖不足是药物不服药的直接原因,导致全移植失败和随后的"不合规"标签.
结论:
- 在移植中延续非描述性语言限制了获得护理的机会,并引入了对器官分配决定的不当主观性.
- 移植委员会必须采用全面的记录实践,准确反映患者的情况.
- 给弱势群体发声和使用精确的语言对于促进移植中的健康公平至关重要.
相关概念视频
Factors Affecting Renal Clearance: Renal Impairment
91
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
91
Renal Failure: Dose Adjustments
88
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
88
Dialysis
307
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
307
Renal Clearance
927
The glomerular filtration rate (GFR) is a critical marker of kidney function, reflecting the efficiency of filtration by the glomeruli. Renal clearance of specific substances, such as inulin or creatinine, is commonly used to measure GFR.
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
Renal clearance refers to the volume of plasma cleared of a specific substance, such as creatinine, per unit of time. To measure clearance, urine samples are collected over a 24-hour period during each bladder voiding, followed by a single blood sample at the...
927
Renal Drug Clearance: Overview
186
Renal clearance is a crucial parameter in pharmacokinetics that quantifies the rate at which the kidneys excrete a drug. It represents a constant fraction of the central volume of distribution containing the drug that the kidney eliminates per unit of time.
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
Renal clearance can be calculated using different methods. One approach is to divide the urinary drug excretion rate by the plasma drug concentration. This method directly measures renal clearance, indicating the kidneys' efficiency in...
186
Renal Drug Excretion: Tubular Secretion
179
Active tubular secretion is a robust, energy-demanding process that utilizes carrier systems to transport drugs into renal tubules. The active renal secretion systems include the organic anion transporter (OAT) for weak acids and the organic cation transporter (OCT) for weak bases. Structurally similar drugs can compete for the same transporter, potentially leading to drug accumulation and toxicity. However, this principle can be exploited therapeutically. One example is probenecid (Probalan),...
179


