评估 gabapentin 剂量,有效性和婴儿安全性
Lauren Fleser1, Erin Tibbetts1, Alison Hanson1
1Department of Pharmacy (LF, ET, AH, ECC, KG, CT), Boston Children's Hospital, Boston, MA.
概括
gabapentin 对于婴儿来说是安全有效的,改善体重和减少疼痛得分,副作用很少. 这项研究为儿科神经病痛和易怒性管理提供了剂量指导.
科学领域:
- 新生儿和儿童药理学新生儿和儿童药理学
- 疼痛管理 疼痛管理
- 神经学 神经学
背景情况:
- 在婴儿治疗神经病痛和易怒等疾病时,加巴丁的使用量有所增加.
- 对于儿科 gabapentin 剂量和结局存在有限的指导.
- 这项研究解决了婴儿 gabapentin 管理中基于证据的实践的需要.
研究的目的:
- 为了描述婴儿 gabapentin 剂量趋势.
- 为了确定有效性结果,包括疼痛和养.
- 在儿童群体中描述 gabapentin 断奶实践.
主要方法:
- 对接受 gabapentin (2015-2021) 的婴儿 (<1岁) 的回顾性单中心研究.
- 主要结局:指示,启动和最大的 gabapentin 剂量.
- 二级结局:死亡率,不良事件,体重与年龄的Z-分数和FLACC分数.
主要成果:
- 66名婴儿接受了 gabapentin;常见的征兆包括易怒和内脏过敏症.
- 平均初始剂量:8.6 mg/kg/天;最大平均剂量:23.2 mg/kg/天.
- 观察到体重对年龄Z分数的显著改善和FLACC分数的降低;报告了三起轻微不良事件.
结论:
- gabapentin 在婴儿中耐受性很好.
- 每24小时服用5毫克/千克/剂量的初始剂量是安全的,并且与现有文献一致.
- gabapentin 显示在改善婴儿结局和最小的不良事件中起到有益作用.
关键词:
gabapentin 是一种药物.婴儿 婴儿 婴儿 婴儿 婴儿易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒易怒新生儿们的新生儿疼痛 疼痛 疼痛 疼痛这是一种内脏性过敏症 (visceral hyperalgesia).更多相关视频
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