包括在内的儿童喘生物标志物:一个探索性横截面研究
Hoda Atef Abdelsattar Ibrahim1,2, Mona Mohsen3, Boles Salep Aziz Hanna3
1Pediatric Clinical Nutrition Unit, Faculty of Medicine, Cairo University, Cairo 12613, Egypt.
World journal of clinical pediatrics
|April 10, 2024
概括
血清含量在患有的儿童和健康儿童之间没有显著差异. 然而,喘儿童的血清费里和免疫球蛋白E水平较高,这表明费里可能表明喘控制.
科学领域:
- 儿科过敏和免疫学
- 营养生物化学 营养生物化学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 儿童支气管喘 (BA) 是一种慢性炎症性呼吸道疾病.
- 营养状况,特别是水平,可能会影响喘等过敏状况.
- 研究喘管理的生物标志物至关重要.
研究的目的:
- 为了比较被诊断患有支气管喘的儿童的血清水平与健康对照组.
- 评估喘儿童血清费里丁,铁,血红蛋白 (Hb) 和免疫球蛋白E (IgE) 的水平.
- 探索这些标志物与喘严重程度之间的潜在相关性.
主要方法:
- 一项涉及40名BA儿童和21名健康儿童的横截面研究.
- 测量了血清中的,费里丁,铁,Hb和IgE水平.
- 统计分析包括独立的t测试,曼-惠特尼测试,克鲁斯卡尔-瓦利斯和斯皮尔曼等级相关性.
主要成果:
- 在喘和健康儿童之间,血清含量没有显著差异 (P=0.115).
- 喘儿童的血清费里 (P=0.006) 和IgE (P=0.001) 水平显著提高.
- 喘严重程度与血清费里或IgE水平没有显著相关.
结论:
- 血清含量似乎不是喘儿童和健康儿童之间的区分因素.
- 血清费里丁水平升高可能是儿童喘控制的潜在指标.
- 在这个队列中,血清IgE水平并不是喘严重程度的可靠标志物.
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