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在低出生体重山羊小羊群中,胰岛素耐药性和脂质失调症

Huihui Song¹, Zhuohang Hao¹, Hehan Feng¹

¹College of Animal Science and Technology, Southwest University, Chongqing Key Laboratory of Herbivore Science, Chongqing, China.

Frontiers in veterinary science

|April 10, 2024

概括

羊的低出生体重会导致胰岛素抵抗和脂质代谢受损,影响整体健康和生长. 这项研究揭示了年轻山羊中这些代谢干扰背后的分子机制.

科学领域:

畜牧科学畜牧科学畜牧科学
代谢研究研究代谢研究
动物生理学动物生理学

背景情况:

低出生体重 (LBW) 对牲畜的发育产生负面影响,导致成年后生长不良和代谢问题.
之前对中国土著山羊的研究表明,LBW小羊的死亡率较高,肝脏脂质不良和肝脏损伤较高.
在LBW牲畜中,将胰岛素抵抗与脂质代谢障碍联系在一起的确切机制在很大程度上是未知的.

研究的目的:

研究胰岛素抵抗机制及其对低出生体重 (LBW) 羊羔脂质代谢的影响.
为了比较LBW和正常出生体重 (NBW) 羊之间的与脂质代谢和胰岛素信号相关的代谢参数和基因表达.

主要方法:

在体内进行葡萄糖和胰岛素耐受性测试以评估代谢功能.
测量了血和骨肌肉的生化参数,包括自由脂肪酸.
进行了转录组分析,以确定参与脂质代谢和胰岛素信号传递的调节途径.

主要成果:

在LBW山羊羔表现出显著的胰岛素耐药性,由葡萄糖/胰岛素耐受性测试和更高的平衡模型评估 (HOMA) 成绩证明.
在LBW山羊中观察到血和骨肌肉自由脂肪酸水平升高.
转录组分析显示脂质代谢和胰岛素信号通路的失调,关键基因的表达发生变化 (例如FABP3,PPARA,LPIN1,DGAT1,ANKRD2,PGC1α,IRS2).

结论:

羊的低出生体重与显著的胰岛素抵抗和受损的脂质代谢有关.
脂质运输,合成,氧化和胰岛素信号的分子干扰有助于LBW山羊的代谢功能障碍.
由LBW干扰肝脏胰岛素功能可能会导致骨肌中的脂质积累,影响牲畜的整体健康和表现.

关键词:

一只山羊,一只山羊.胰岛素耐药性是一种胰岛素耐药性.脂质的积累脂质的积累出生时体重较低的婴儿.这是骨肌肉的骨架肌肉.

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