制阻燃剂与心血管疾病之间的单一和组合相关性:一项大型横截面研究
Wenhao Yin1, Rui Xu1, Jiyu Zou2
1Department of Cardiovascular Medicine, Liaoning University of Traditional Chinese Medicine, Shenyang, China.
暴露于制阻燃剂 (BFRs) 会增加美国成年人心血管疾病 (CVD) 的风险,特别是 PBB153. 需要进一步的研究来证实这些关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 心脏病学 心脏病学
背景情况:
- 制阻燃剂 (BFR) 与心血管疾病 (CVD) 之间的关联尚未完全理解.
- BFR是广泛使用的化学物质,具有潜在的健康影响.
研究的目的:
- 调查BFR暴露和心血管疾病之间的联合和个人关联.
- 探索BFR混合物与心血管健康结果之间的关系.
主要方法:
- 利用了国家健康和营养检查调查 (2005-2016) 中的7032名成年参与者的数据.
- 应用加权量子总和 (WQS) 和量子G计算 (QGC) 模型来评估结合的BFRs效应.
- 分析了特定BFR (PBB153, PBB99, PBB154) 和心血管疾病亚型之间的关联.
主要成果:
- PBB153的高四分位数显示出与心血管疾病有显著的积极关联 (OR:19.2;95%CI:10.9,34.0).
- PBB153, PBB99和 PBB154与充血性心力衰竭有关.
- 在总体BFR混合物和心血管疾病之间观察到正相关性 (OR:1.23;95%CI:1.03,1.47).
结论:
- 暴露于BFRs,特别是 PBB153,与美国成年人心血管疾病风险增加有关.
- 这些发现凸显了BFR混合物的潜在心血管风险.
- 建议进行进一步的大规模队列研究来验证这些结果.
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