精神分裂症患者肠道微生物群的变化
Zhuocan Li1, Xiangkun Tao1, Dongfang Wang1,2,3
1National Health Commission (NHC) Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Frontiers in psychiatry
|April 10, 2024
概括
精神分裂症可能与肠道细菌的变化有关. 这项研究发现患者的特定细菌持续增加或减少,这表明针对肠道微生物群的新诊断和治疗方法的潜力.
科学领域:
- 微生物组研究的研究.
- 精神疾病 精神疾病
- 肠-大脑轴 肠-大脑轴
背景情况:
- 精神分裂症的分子基础在很大程度上是未知的.
- 肠道微生物组越来越多地通过肠-大脑轴参与大脑功能.
- 以前的研究表明,精神分裂症患者的肠道微生物群发生了不一致的变化.
研究的目的:
- 在精神分裂症中识别持续改变的肠道微生物种群.
- 综合人类肠道微生物组关于精神分裂症的研究结果.
- 为了研究混因子对肠道微生物群变化的影响.
主要方法:
- 系统的文献搜索和综合人类肠道微生物组关于精神分裂症的研究.
- 投票计数分析以识别持续变化的微生物种群.
- 对影响肠道微生物群的潜在混因素的分析.
主要成果:
- 患者和对照组之间在α-多样性或β-多样性上没有显著差异.
- 在精神分裂症中,有八种肠道微生物分类系统持续上调调节:蛋白质细菌,蛋白质细菌,乳酸细菌,肠杆菌,乳酸细菌,Succinivibrio,Prevotella和Acidaminococcus.
- 五种肠道微生物种群在精神分裂症中持续下调:Fusicatenibacter,Faecalibacterium,Roseburia,Coprococcus和Anaerostipes. 这五种肠道微生物种群在精神分裂症中持续下调.
结论:
- 与精神分裂症相关的肠道微生物群变化涉及抗炎性酸盐生产物的耗尽和机会性细菌的丰富.
- 这些发现有助于理解肠道微生物组在精神分裂症发病过程中的作用.
- 鉴定的微生物模式可以为基于微生物群的精神分裂症诊断和治疗策略提供信息.
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