TSH受体降低了血红蛋白S聚合,增加了红细胞的可变性和粘附性
Evelyn Mendonça-Reis1,2, Camila Cristina Guimarães-Nobre1,2, Lyzes Rosa Teixeira-Alves1,2
1Grupo de Pesquisa em Fisiologia Eritróide-GPFisEri, Universidade Federal do Rio de Janeiro, Campus Macaé, Rio de Janeiro, Brazil.
Anemia
|April 10, 2024
概括
甲状腺刺激激素 (TSH) 可能在状细胞病 (SCD) 中发挥作用. 发现TSH可以降低HbS聚合,并改善SCD患者的红细胞变形性.
科学领域:
- 血液学 血液学 血液学
- 内分泌学 在内分泌学.
- 分子生物学分子生物学
背景情况:
- 状细胞病 (SCD) 是一种遗传性血液疾病,由β-环球蛋白基因突变引起,导致血红蛋白异常 (HbS) 和状红细胞在缺氧下.
- 内分泌疾病在SCD患者中很常见,甲状腺功能低下影响约7%.
- 已确定成熟的红细胞具有TSH受体,这表明TSH和SCD中的红细胞功能之间存在潜在的联系.
研究的目的:
- 研究甲状腺刺激激素 (TSH) 对状细胞疾病 (SCD) 患者的红细胞的影响.
- 评估TSH对HbS聚合,红细胞变形性和粘附性质的影响.
主要方法:
- 从SCD患者的红细胞在低氧条件下暴露于不同度的TSH (1,2,3和5mIU/L).
- 在暴露30分钟后测量HbS聚合.
- 使用Sephacryl-S 500列评估了红细胞的变形性.
- 静态粘附测试使用血栓胺进行,以评估红细胞粘附.
主要成果:
- 在所有测试度中,TSH显著降低了HbS聚合.
- 红细胞的变形性在存在TSH时增加.
- 在较低的TSH度 (1和2 mIU/L) 时,红细胞对血栓胺的粘附性增加,但在较高的度 (3和5 mIU/L) 时没有显著改变.
结论:
- TSH在状细胞疾病的病理生理学中发挥了潜在的作用.
- TSH抑制了HbS的聚合,并积极调节了红细胞的变形性.
- TSH会影响红细胞对血栓状腺素的静态粘附,其影响取决于度.
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