单元突触电流的比较由间接和直接途径神经元产生的小鼠条体的神经元
James A Jones1,2, Jacob Peña1, Rostislav I Likhotvorik1
1Department of Neuroscience, Developmental and Regenerative Biology, University of Texas at San Antonio, San Antonio, Texas, United States.
Journal of neurophysiology
|April 10, 2024
概括
直接和间接通路的条状神经元 (SPNs) 同样影响外部球神经元 (GPe). 虽然大多数SPN-GPe连接是弱的,但有些是强的,影响GPe神经元活动.
科学领域:
- 神经科学是一个神经科学.
- 细胞神经科学 细胞神经科学
- 系统神经科学 系统神经科学
背景情况:
- 基底使用直接 (dSPN) 和间接 (iSPN) 途径来调节运动控制.
- 无论是dSPN还是iSPN都投射到外部的白色球体 (GPe),但它们的不同角色仍在争论中.
- 之前的研究表明,激活dSPN和iSPN终端场的行为影响不同.
研究的目的:
- 调查单个dSPN和iSPN是否对单个GPe神经元产生相似或不同的突触效应.
- 描述从已识别的SPN亚型到GPe神经元上的单元突触电流的特性.
主要方法:
- 用光遗传刺激来唤起单条纹状棘状投影神经元 (SPN) 中的动作潜力.
- 在SPN激活后,在GPe神经元中记录了单元抑制后突触电流 (IPSC).
- 测量了GPe神经元中的膜潜在变化,以评估突触电流对发射的影响.
主要成果:
- 在单个iSPN与单个dSPN引起的单元IPSC的振幅上没有发现显著差异.
- 大多数SPN-to-GPe连接是弱的,但来自这两种途径的连接子集显著更强.
- 来自iSPN和dSPN的大型单元突触潜力同样改变了GPe神经元尖峰时间.
结论:
- 个别的iSPN和dSPN可以对GPe神经元产生类似的突触影响.
- SPN输入对GPe神经元的功能影响取决于连接强度,强连接的子集是个别影响的.
- GPe神经元从直接和间接通路接收收的输入,连接强度各不相同.
相关概念视频
01:28Electrical Synapses
Electrical synapses found in all nervous systems play important and unique roles. In these synapses, the presynaptic and postsynaptic membranes are very close together (3.5 nm) and are actually physically connected by channel proteins forming gap junctions.
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
Gap junctions allow the current to pass directly from one cell to the next. In contrast, in the chemical synapse, the neurotransmitters carry the information through the synaptic cleft from one neuron to the next. They consist of two...
01:21Electrochemical Gradient and Channel Proteins: An Overview
An electrochemical gradient is a fundamental concept in biology and chemistry. It regulates the movement of ions across cell membranes. This movement is influenced by two factors:
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
The electrical gradient: The electrical gradient across cell membranes refers to the difference in electric charge between the inside and outside of a cell. This difference drives the movement of ions towards or away from the cells. For instance, if the inside of the cell is more negatively charged relative to the...
01:28Neuronal Communication
Neurons, the fundamental units of the brain and nervous system, communicate through complex electrochemical signals that underpin all cognitive and bodily functions. This communication is primarily facilitated by a process involving the generation and propagation of an action potential along the axon of the neuron. When the internal electrical charge of a neuron surpasses a certain threshold, an action potential is triggered. This rapid change in voltage travels swiftly along the axon to the...