Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Sex-linked Disorders01:43

Sex-linked Disorders

102.1K
Like autosomes, sex chromosomes contain a variety of genes necessary for normal body function. When a mutation in one of these genes results in biological deficits, the disorder is considered sex-linked.
102.1K
Neural Regulation01:37

Neural Regulation

39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
Conjugated Proteins02:50

Conjugated Proteins

18.3K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
18.3K
Amyloid Fibrils03:03

Amyloid Fibrils

9.5K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.5K
Fibril-associated Collagen01:11

Fibril-associated Collagen

2.5K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
2.5K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Alpha-Synuclein Seed Amplification Assay in CSF, Skin, and Submandibular Gland From Incidental Lewy Body Disease and Parkinson Disease.

Neurology·2026
Same author

Dose-dependent white matter changes associated with repetitive head impacts in former American football players.

Brain communications·2026
Same author

Tau topography subtypes account for clinical heterogeneity and longitudinal trajectories in early-onset Alzheimer's disease.

Brain communications·2026
Same author

Multisite study: Predicting Lewy body disease using skin biopsy α-synuclein seed amplification assays.

Journal of neuropathology and experimental neurology·2026
Same author

Plain language summary: the evoke(+) studies of semaglutide for early Alzheimer's disease.

Neurodegenerative disease management·2026
Same author

A plasma protein signature for cerebral amyloid angiopathy.

Acta neuropathologica·2026

相关实验视频

Updated: Jun 28, 2025

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
10:03

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

10.6K

配偶同核蛋白病变:一个临床病理学研究

Charles H Adler1, Matthew Halverson2, Nan Zhang3

  • 1Department of Neurology, Mayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, Arizona, USA.

Movement disorders : official journal of the Movement Disorder Society
|April 10, 2024
PubMed
概括

配偶之间对人类的突核蛋白病变的传播不太可能. 一项对90对夫妇的研究发现,只有16例情况下,双方都患有同核因子病变,如帕金森病或勒维体痴呆症.

关键词:
阿尔茨海默病的疾病阿尔茨海默病的疾病.帕金森病的疾病.婚姻关系的婚姻关系.患有利维体痴呆症的痴呆症神经病理学神经病理学

更多相关视频

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
08:33

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

Published on: June 25, 2019

8.2K
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

17.3K

相关实验视频

Last Updated: Jun 28, 2025

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
10:03

Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons

Published on: August 16, 2020

10.6K
Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay
08:33

Targeting Alpha Synuclein Aggregates in Cutaneous Peripheral Nerve Fibers by Free-floating Immunofluorescence Assay

Published on: June 25, 2019

8.2K
Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains
09:27

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

Published on: January 5, 2016

17.3K

科学领域:

  • 神经科学是一个神经科学.
  • 病理学 病理学 病理学
  • 流行病学 流行病学

背景情况:

  • 临床前研究表明,α-synuclein可以通过细胞间传播传播.
  • 同核蛋白病变的人对人传播潜力仍然是未知的.

研究的目的:

  • 为了调查尸体解剖后的婚姻夫妇中发生的同核蛋白病变.
  • 评估配偶之间的同核蛋白病变传播的可能性.

主要方法:

  • 对90个已故的夫妻进行神经病理学检查.
  • 发现被分类为帕金森病 (PD),患有勒维体的痴呆症 (DLB),患有勒维体的阿尔茨海默病 (ADLB),偶发的勒维体疾病 (ILBD) 或没有勒维体.

主要成果:

  • 在90对夫妇中,32对没有莱维体.
  • 42对夫妇中有一个配偶患有同核蛋白病变 (10个PD,3个DLB,13个ADLB,16个ILBD).
  • 16对夫妇的配偶都患有同核蛋白病变,PD,DLB和ADLB的组合各不相同.

结论:

  • 在配偶之间传播同核蛋白病变似乎不太可能.
  • 这项对90对婚姻夫妇的研究提供了证据,证明了同核蛋白病变的显著人对人传播.