估计的脉冲波速度和新发性心力衰竭的风险
Chunpeng Ji1, Guodong Wang2, Zhe Huang1
1Department of Cardiology, Kailuan General Hospital, No. 57 Xinhua Rd (East), Tangshan, 063000, China.
ESC heart failure
|April 10, 2024
概括
估计的脉冲波速度 (ePWV) 独立预测新发的心力衰竭. 较高的ePWV水平在不同人群中显著增加心力衰竭风险,改善风险预测模型.
科学领域:
- 心脏病学 心脏病学
- 血管生物学 血管生物学
- 流行病学 流行病学
背景情况:
- 估计的脉冲波速率 (ePWV) 是一个验证的带-大腿脉冲波速率的替代品,也是心血管事件的预测指标.
- 需要进一步证实,ePWV与患心力衰竭 (HF) 风险之间的关联需要进一步证实.
研究的目的:
- 调查ePWV与新发性心力衰竭风险之间的关联.
- 在一项大型队列研究中评估ePWV对事件HF的预测能力.
主要方法:
- 一组98,269名以前没有HF的员工被跟踪了平均13.85年.
- 考克斯的比例危险模型和接收器运行特征曲线分析被用来评估ePWV的预测值.
- 净重新分类指数 (NRI) 被计算出来,以评估心血管风险模型的改善,并添加了ePWV.
主要成果:
- 在预测心力衰竭方面,ePWV显示曲线下的面积 (AUC) 为0.74.
- 经过对传统风险因素进行调整后,每1m/s的ePWV增加都与新发性HF风险增加35%有关 (HR: 1.35,95% CI: 1.33-1.37).
- ePWV在各种子组中显著预测了事件HF,并且在添加到传统模型 (NRI = 0.311) 时将风险重新分类提高了31.1%.
结论:
- 估计的脉冲波速度 (ePWV) 是新发性心力衰竭的独立预测指标.
- ePWV增强了心血管风险分层对心力衰竭的发展.
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