淋巴系统功能障碍与大脑功能和结构的改变之间的关联在患有白质过强度的患者中
Zhang Zhi1,2,3, Xiao Liang1,2,3, Muhua Huang4
1Department of Radiology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University.
Neuroreport
|April 10, 2024
概括
淋巴系统损伤,通过较低的周围血管空间 (ALPS) 指数表明,与白质强度过高 (WMH) 患者的改变大脑功能有关. 这种功能障碍与特定的大脑区域连接相关,这表明它在WMH病理学中发挥了作用.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 生物医学工程 生物医学工程
背景情况:
- 白质超强度 (WMH) 在衰老和脑血管疾病中很常见,通常与认知能力下降有关.
- 负责大脑中废物清理的淋巴系统,越来越多地被认为是它在神经健康中的作用.
- 之前的研究表明,淋巴功能障碍可能导致WMH的发病,但其与大脑结构和功能的具体关系尚不清楚.
研究的目的:
- 通过沿周血管空间 (ALPS) 指数评估的淋巴系统功能与WMH患者的大脑结构和功能改变之间的关联.
- 探索淋巴体指数与各种MRI衍生脑力指标之间的相关性,包括皮质厚度,皮质面积和静止状态功能连接.
主要方法:
- 磁共振成像 (MRI) 数据来自27名WMH患者和23名健康对照.
- 结构指标包括ALPS指数,心室大小,皮质厚度和皮质面积.
- 从静止状态fMRI中获得的功能指标包括区域均性,度中心性,低频波动幅度 (ALFF),低频波动的分数幅度 (fALFF) 和voxel-mirrored homotopic connectivity (VMHC).
主要成果:
- 与健康对照组相比,WMH患者的ALPS指数明显较低.
- 在一些大脑区域,WMH患者的ALFF,fALFF,区域同质性,中心度和VMHC值发生变化,以及皮层厚度和面积的变化趋势.
- 发现左侧ALPS指数与上回形中中心度之间存在显著的正相关性.
结论:
- 淋巴系统损伤,由降低ALPS指数证明,与WMH患者的大脑功能中心性的改变有关.
- 这些发现表明,淋巴管功能障碍可能在WMH和相关认知障碍的病理生理学中发挥关键作用.
- 这项研究为WMH人群中认知缺陷背后的机制提供了新的视角.
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