大口径实证食道扩张在非阻断性失消症患者中获得持续改善的结果
Nir Bar1,2, Mythili Pathipati1, Kyle Staller1
1Center for Neurointestinal Health, Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Clinical and translational gastroenterology
|April 10, 2024
概括
经验性食道扩张 (EED) 对于非阻塞性消化不全 (NOD) 是安全有效的,特别是在发生组织破坏时. 这种治疗可为患有固体食物失调症的患者提供持久的症状改善.
科学领域:
- 胃肠病学 胃肠病学
- 食道疾病 食道疾病
- 吞功能 吞功能
背景情况:
- 经验性食道扩张 (EED) 对于非阻塞性消化不全 (NOD) 是由于安全性和疗效方面的担忧而引起的争论.
- 这项研究调查了EED后的症状反应,组织破坏和不良事件.
研究的目的:
- 评估大口径布吉EED的安全性和有效性,用于管理非阻塞性消化不良 (NOD).
- 评估症状的改善,并确定影响治疗成功的因素.
主要方法:
- 在180名接受EED的患者中,对不良事件 (AE) 的回顾性审查.
- 使用NIH患者报告结果测量信息系统 (PROMIS) 对吞失调的前性评估问卷.
- 对食道计量进行了审查,以确定阻塞性运动障碍.
主要成果:
- 在NOD中使用大型口径EED的低AE率 (0.5%孔径) .
- 可见组织破坏发生在18%的患者中,在阻塞性运动障碍患者中更为频繁 (44%对14%).
- 观察到显著和持久的功能障碍的改善,特别是固体食物,特别是在组织破坏的患者中.
结论:
- 经验性食道扩张 (EED) 是一种安全有效的治疗非阻塞性消化障碍症 (NOD),特别是固体食物消化障碍症.
- 在EED期间的组织破坏并不排除潜在的食道动力障碍.
- 当存在组织破坏时,EED表现出特别有效.
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