在韩国,艾滋病毒感染的成年人中,肥胖与癌症风险之间的关联
Yoonyoung Jang1,2, Taehwa Kim1,3, Yunsu Choi1
1Department of Preventive Medicine, Hanyang University College of Medicine.
AIDS (London, England)
|April 10, 2024
概括
肥胖与艾滋病毒感染成人的非艾滋病定义癌症的风险更高有关. 然而,肥胖并没有增加该人群中艾滋病定义癌症的风险.
科学领域:
- 流行病学 流行病学
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
背景情况:
- 肥胖是人类免疫缺陷病毒 (HIV) 感染的管理中日益关注的问题.
- 了解艾滋病毒成年人肥胖和癌症风险之间的关系对于临床护理至关重要.
研究的目的:
- 调查艾滋病毒感染成人的肥胖和整体癌症风险之间的关联.
- 检查肥胖与特定地点的癌症风险之间的联系,包括艾滋病定义和非艾滋病定义的癌症,在这个人群中.
主要方法:
- 使用韩国全国健康查数据库进行了嵌套病例控制研究.
- 数据包括2004年至2020年期间被诊断患有艾滋病毒的16671名成年人.
- 肥胖症被定义为身体质量指数 (BMI) ≥25 kg/m2,并使用几率比率 (OR) 和95%置信区间 (95%CI) 分析了相关性.
主要成果:
- 患有艾滋病毒的肥胖成年人患非艾滋病确定的癌症的风险明显更高 (OR=1.478,95% CI=1.118-1.955).
- 没有观察到艾滋病定义癌症 (OR=0.816,95%CI=0.520-1.279) 或特定类型 (如卡波西肉瘤和非霍奇金淋巴瘤) 的风险增加.
- 肥胖与结直肠癌 (OR=3.090,95% CI=1.110-8.604) 和肝脏,胆道和胰腺癌 (OR=2.532,95% CI=1.141-5.617) 的风险增加有关.
结论:
- 肥胖是艾滋病毒管理中重要的健康考虑因素.
- 肥胖与艾滋病毒感染的成年人患非艾滋病确定的癌症的风险增加有关.
- 在这个人群中,肥胖似乎没有增加艾滋病定义癌症的风险.
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