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VEGF-2578C/A,-460T/C 多态性和胃肠道癌症风险:一个更新的元分析

Deepanshi Mahajan¹, Vasudha Sambyal¹, Manjit Singh Uppal²

¹Human Cytogenetics Laboratory, Department of Human Genetics, Guru Nanak Dev University, Amritsar, Punjab, India.

Genetic testing and molecular biomarkers

|April 10, 2024

概括

血管内皮生长因子 (VEGF) 的特定基因变异与胃肠道 (GIT) 癌症风险有关. 这项研究发现,VEGF-2578C/A和VEGF-460T/C的多态性增加了食道癌和其他GIT癌症的风险.

科学领域:

遗传学遗传学是一个
在瘤学瘤学.
分子生物学分子生物学

背景情况:

血管内皮生长因子 (VEGF) 在血管生成和瘤生长中起着至关重要的作用.
在VEGF基因中的功能多态性可以影响对各种癌症的易感性.
关于VEGF多态和胃肠道 (GIT) 癌症风险的先前研究得出了不确定的结果.

研究的目的:

调查VEGF-2578C/A和VEGF-460T/C多形体与食道癌 (EC) 风险之间的关联.
进行元分析,以全面评估这些VEGF多态与整体GIT癌症风险的关联.

主要方法:

在330名EC患者和330名对照人群中,对VEGF-2578C/A多态的基因定型.
316名EC患者和316名对照人群的基因定型,以检测VEGF-460T/C多态.
在PubMed,ScienceDirect和Google Scholar的系统文献搜索中进行元分析,包括21项关于VEGF-2578C/A和20项关于VEGF-460T/C的研究.

主要成果:

VEGF-2578C/A的AA基因型和A等位基因与EC风险增加显著相关 (p=0.01,p=0.02).
维格-460T/C的CC基因型和C等位基因与EC风险增加显著相关 (p=0.04).
分析显示,VEGF-2578C/A与整体GIT癌症风险降低有关 (p=0.009) 以及特定种族和癌症类型 (胆囊).
VEGF-460T/C与高加索人增加GIT癌症风险有关,特别是肝细胞癌,胃癌和结直肠癌.

结论:

VEGF-2578C/A和VEGF-460T/C多态性与患上各种胃肠道癌症的风险变化有关.
这些发现强调了特定的VEGF遗传变异在不同人群和癌症类型的GIT癌症易感性中的作用.

关键词:

肠胃肠道癌症是什么意思在VEGF中,VEGF是VEGF.这是食道癌的癌症.这是一个元分析.多形态主义的多态主义.

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