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Updated: Jun 28, 2025

Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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原始识别复合体有序和无序区域的直接差异 in vivo 结合在不同的动图序列

Michal Chappleboim1, Segev Naveh-Tassa2, Miri Carmi1

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Nucleic acids research
|April 10, 2024
PubMed
概括

起源识别复合体 (ORC) 使用无序的基本补丁来绑定酵母中的DNA复制起源. 不同的ORC元素在各种基因组部位指导结合,揭示了关键的DNA识别机制.

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Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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