身体活动与发展炎症性肠病的风险降低有关:系统审查和元分析
Ho Tuan Tiong1, Dali Fan1, Chris Frampton2
1Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand.
Journal of Crohn's & colitis
|April 10, 2024
概括
定期体育活动可以降低患炎症性肠病 (IBD) 的风险. 这次元分析发现,身体活动和IBD风险之间存在显著的反向关联,特别是对于克罗恩病.
科学领域:
- 胃肠病学 胃肠病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 炎症性肠病 (IBD) 包括诸如克罗恩病 (CD) 和性结肠炎 (UC) 等慢性疾病.
- 包括体力活动在内的可修改的生活方式因素正在被调查,以确定它们在IBD预防中的潜在作用.
- 之前关于身体活动和IBD风险的研究已经产生了不一致的结果.
研究的目的:
- 进行系统审查和元分析.
- 估计身体活动对IBD发展风险的影响.
主要方法:
- 对2023年4月之前发表的研究进行了全面的文献搜索.
- 包括的研究评估了诊断前身体活动水平与IBD发病率之间的关联.
- 来自10项观察性研究的数据使用元分析进行了综合分析,证据质量通过GRADE方法进行评估.
主要成果:
- 在队列 (RR 0.78,95% CI 0.68-0.88) 和病例对照研究 (RR 0.87,95% CI 0.79-0.95) 中,高水平的体力活动与克罗恩病 (CD) 的风险降低有关.
- 对于性结肠炎 (UC),高体力活动在队列研究中显示风险降低 (RR 0.62,95% CI 0.43-0.88),但在病例对照研究中没有显著的影响 (RR 0.74,95% CI 0.51-1.07).
- 该元分析包括来自86万多名参与者的数据.
结论:
- 身体活动与发展IBD的风险有相反的关联.
- 与性结肠炎相比,身体活动的保护作用在克罗恩病中似乎更强.
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