牙真菌干细胞衍生的外体通过优化施瓦恩细胞功能来促进坐骨神经再生
Ying Chai1,2,3,4,5,6,7, Yuemin Liu1,2,3,4,5,6,7, Zhiyang Liu1,2,3,4,5,6,7
1Department of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Cellular reprogramming
|April 10, 2024
概括
牙髓干细胞衍生的外体细胞 (DPSC-exos) 显示出对外围神经修复的前景. 这些外体在动物模型中显著增强神经再生和功能恢复,提供了潜在的治疗策略.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 神经科学是一个神经科学.
背景情况:
- 尽管最近取得了进展,但外围神经损伤的修复仍然是一个临床挑战.
- 从牙髓干细胞 (DPSC-exos) 衍生出来的外体细胞显示了神经再生的潜力.
研究的目的:
- 评估人类DPSC-exos在促进外围神经再生方面的疗效.
- 为了研究DPSC-exos在老鼠坐骨神经损伤模型中的治疗潜力.
主要方法:
- 在实验室内共培养牙髓干细胞 (DPSCs) 和施万细胞 (SCs).
- 人类DPSC-exos的提取,标记和吸收实验在背部根质神经元 (DRGs) 和SCs.
- 建立大鼠坐骨神经损伤模型,用于体内评估.
主要成果:
- 通过增强SC增殖,迁移和神经营养因子分泌,DPSC-exos促进了神经细胞延长.
- 在体内给药DPSC-exos改善了受伤大鼠的行走行为,轴突再生和髓化.
结论:
- 人类DPSC-exos显著增强周围神经的再生和功能恢复.
- DPSC-exos代表了组织工程神经修复的有希望的治疗工具.
更多相关视频
09:17Dorsal Root Ganglia Neurons and Differentiated Adipose-derived Stem Cells: An In Vitro Co-culture Model to Study Peripheral Nerve Regeneration
Published on: February 26, 2015
21.4K
10:16Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells
Published on: June 14, 2017
7.3K
相关概念视频
Stem Cell Therapy for Tissue Regeneration
4.0K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.0K
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
