相关实验视频
Updated: Jun 28, 2025

10:32
Development of a Virtual Reality Assessment of Everyday Living Skills
Published on: April 23, 2014
18.5K
同时服用益生菌和维生素D显著改善精神分裂症患者的认知功能:一项双盲随机对照试验
Aida Mohammadi1, Gita Sadighi2, Ali Nazeri Astaneh2
1Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Neuropsychopharmacology reports
|April 10, 2024
概括
益生菌和维生素D补充剂改善了精神分裂症患者的认知功能. 虽然疾病严重程度得分没有显著变化,但胆固醇和炎症等关键健康标志物有所改善.
科学领域:
- 精神病学和神经科学 精神病学和神经科学
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 精神分裂症与认知缺陷和改变的肠道微生物组有关.
- 在精神分裂症患者中,维生素D缺乏是常见的.
- 肠道微生物组调节和维生素D补充显示了管理精神病症状的潜力.
研究的目的:
- 评估联合益生菌和维生素D补充剂对精神分裂症患者认知功能和疾病严重程度的影响.
- 评估二次结果,包括脂质概况,BMI,胃肠道问题和炎症标志物.
主要方法:
- 一项随机对照试验,涉及70名精神分裂症患者 (18-65岁).
- 参与者被分配到安慰剂组 (n=35) 或干预组 (n=35) 中,接受益生菌补充剂和400 IU维生素D.
- 用蒙特利尔认知评估 (MoCA) 评估认知功能,通过正负综合征量表 (PANSS) 评估疾病严重程度.
主要成果:
- 干预组的MoCA得分显著增加 (1.96个单位,p=0.004) 和获得MoCA得分≥26 (p=0.031) 的参与者的比例更高.
- 与安慰剂相比,补充剂组的总胆固醇 (TC),禁食血糖 (FBS) 和C反应蛋白 (CRP) 显著降低.
- 虽然益生菌补充剂组的PANSS分数有所下降,但这种差异在统计学上并不显著 (p=0.247).
结论:
- 同时服用益生菌和维生素D为改善精神分裂症患者的认知功能提供了显著的好处.
- 这种补充策略也对代谢和炎症标志物产生了积极的影响,表明了更广泛的治疗潜力.
相关概念视频
Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
Alzheimer's Disease: Treatment
183
Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
183
Psychosis and Antipsychotic Drugs: Overview
246
The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
246
Biological Causes of Schizophrenia
55
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
55
Antidepressant Drugs: Overview
466
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
466
Psychosis: Goals of Pharmacotherapy
124
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
124

