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选择性可塑性层2/3输入到远端前肢控制层5皮层脊髓神经元与熟练的掌握运动训练
Yoshio Takashima1, Jeremy S Biane2, Mark H Tuszynski3
1Department of Neurosciences, UCSD, La Jolla, CA 92093, USA.
Cell reports
|April 10, 2024
概括
运动学习加强皮质层之间的特定连接. 熟练的掌握训练增强了对控制远端前肢运动的皮质脊髓神经元的2/3层输入.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 突触性可塑性 突触性可塑性
背景情况:
- 新皮质中的5层神经元从2/3层神经元接收初级输入.
- 了解运动学习过程中这些投影的可塑性至关重要.
研究的目的:
- 在运动学习过程中,研究2/3层到5层皮质投射的可塑性.
- 为了确定这些输入如何随着熟练的掌握培训而改变.
主要方法:
- 利用光遗传学和病毒交叉工具在老鼠初级运动皮层中进行选择性神经元刺激.
- 同时从控制远端与近端前肢运动的皮质脊髓神经元记录.
主要成果:
- 在未经训练的老鼠中,二/三层输入显示出近接前肢神经元的激发更大.
- 熟练的掌握训练显著加强了对前肢远端皮质脊髓神经元的2/3层输入.
- 训练增加了响应幅度,缩短了延迟时间,并延长了刺激到抑制的延迟时间.
结论:
- 展示了层2/3投射的明显和细胞特异性可塑性.
- 这些变化是分离的,并与熟练的掌握运动学习联系在一起.
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