从4个随机对照试验中,在免疫系统受损的参与者中发现COVID-19疫苗的有效性
Amy C Sherman1, Jessica Tuan2, Valeria D Cantos3
1Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
概括
对于具有温和免疫系统 (TIS) 的个人,包括那些有轻度免疫损害条件的人,COVID-19疫苗的疗效仍然很高. 这些发现支持更广泛的人群接种疫苗,确保对症状和严重疾病提供可比的保护.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 传染性疾病 传染性疾病
背景情况:
- 严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 疫苗在一般人群中显示出高效.
- 有限的数据存在于疫苗有效性 (VE) 对于有轻度免疫损害条件的个体.
研究的目的:
- 为了评估VE对症状和严重的COVID-19在"温和免疫系统" (TIS) 的个人.
- 为了在四个主要的COVID-19疫苗试验中比较TIS参与者与非TIS个人的VE.
主要方法:
- 来自四个随机,安慰剂控制的COVID-19疫苗试验 (Moderna,AstraZeneca,Janssen,Novavax) 的参与者级数据的后期分析.
- 根据病史和药物定义TIS;分析了针对症状和严重COVID-19的VE.
- 包括对受控良好的人类免疫缺陷病毒的参与者的分析.
主要成果:
- 在整个试验中,很大一部分参与者被确定为TIS (10.312.7%),主要是由于代谢/营养障碍.
- 在所有参与者中,接种疫苗显著减少了症状和严重的COVID-19.
- 在TIS和非TIS参与者之间没有观察到对症状或严重COVID-19的VE的显著差异.
结论:
- 患有轻度免疫损害性疾病 (TIS) 的人与非TIS人对症状和严重的COVID-19呈现相似的VE.
- 这些发现支持当前的COVID-19疫苗在更广泛的人口范围内的有效性.
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