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Updated: Jun 28, 2025

Residue-Specific Exchange of Proline by Proline Analogs in Fluorescent Proteins: How "Molecular Surgery" of the Backbone Affects Folding and Stability
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4,4-Difluoroproline作为一个独特的F NMR探测器的proline构造

Himal K Ganguly1, Brice A Ludwig1, Caitlin M Tressler1

  • 1Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716, United States.

Biochemistry
|April 10, 2024
PubMed
概括

4,4-Difluoroproline (Dfp) 是一种新型的探针,用于研究使用19F NMR. 它揭示了proline环的偏好和cis-trans异构体,有助于蛋白质折叠和疾病研究.

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