相关实验视频

Updated: Jun 8, 2026

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization
09:19

Strategic Screening and Characterization of the Visual GPCR-mini-G Protein Signaling Complex for Successful Crystallization

Published on: March 16, 2020

7.0K

化学多样性的"超级支架"图书馆的虚拟选使关键的GPCR标的干发现成为可能

Katharina Grotsch1,2, Anastasiia V Sadybekov3, Sydney Hiller1,2

  • 1Department of Chemistry, the Bridge Institute, University of Southern California, Los Angeles 90089, California, United States.

ACS chemical biology
|April 10, 2024
PubMed
概括

超大虚拟选使用新的硫化物化学创造了数百万种化合物. 这种方法成功地识别了大麻素II型受体 (CB2) 抗剂,成功率为55%,加速了药物发现.

更多相关视频

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

12.3K
Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery06:26

Nano-Differential Scanning Fluorimetry for Screening in Fragment-based Lead Discovery

Published on: May 16, 2021

4.8K

相关概念视频

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...