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多发性硬化症患者中原发性头痛的发生率

Maged Abdel Naseer¹, Hatem Samir Shehata¹, Sarah Khalil¹

¹Neurology Department, Faculty of Medicine, Cairo University, Egypt.

Multiple sclerosis and related disorders

|April 10, 2024

概括

主要头痛,包括偏头痛和紧张型头痛,在多发性硬化症 (MS) 患者中很常见. 某些疾病修饰疗法和MS病变位置会影响头痛的发生和严重程度.

科学领域:

神经学神经学
神经免疫学神经免疫学
头痛医学医学医学

背景情况:

多发性硬化症 (MS) 是一种主要的免疫媒介性中枢神经系统炎症性疾病.
头痛,特别是偏头痛和紧张型头痛 (TTH),在MS患者中经常被报告.
对于MS而言,疾病修饰剂 (DMA) 可能会影响头痛模式.

研究的目的:

为了确定MS患者初级头痛的患病率和临床特征.
调查头痛和MS临床特征之间的关联,包括疾病过程,持续时间,残疾 (EDSS),脑成像和DMAs.

主要方法:

一项研究包括281名通过麦当劳标准 (2017) 诊断的MS患者.
从医疗记录和患者采访中收集数据,使用经过验证的阿拉伯语问卷.
在报告头痛的患者中评估了头痛的特征和模式.

主要成果:

紧张型头痛 (TTH) 在男性中更为普遍,这些男性的EDSS得分较高,以及SPMS/PPMS表型,并且与rituximab或cyclophosphamide相关.
偏头痛更常见于女性,患有较低EDSS,RRMS表型,周水管灰色病变的患者,以及接受INF或fingolimod的患者.
干扰素 (IFN) 增加了头痛风险,而利图西马布则降低了风险. 周水管道灰色病变与频繁的头痛相关,感觉运动病变与严重的头痛相关.

结论:

主要头痛在MS患者中非常普遍,偏头痛和TTH是常见的.
多发性硬化病变的病变位置,特别是水管灰色部分,以及特定的DMAs显著影响头痛的频率和严重程度.
干扰素治疗与头痛风险增加有关,而修复药与风险降低有关.

关键词:

大人的成年人.在 DMD DMD 里面,你会发现头痛是一种头痛.在MSMSMSMSMSMSMSMSMSMSMS中,我们可以看到偏头痛和TTH和TTH之间的关系

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