孤独性骨质血清细胞瘤:在一个中心的长期临床结果
Shan Gao1, Yu-Tong Wang1, Guang-Yu Ma2
1Department of Hematology, Beijing Jishuitan Hospital, Capital Medical University, Beijing 100035, China.
Current problems in cancer
|April 10, 2024
概括
骨单体血瘤 (SBP) 经常发展为多发性骨髓瘤 (MM). 建议在SBP管理中进行辅助化疗,以改善患者的治疗结果并降低进展率.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 骨疾病 骨疾病
背景情况:
- 孤独性等离子细胞瘤 (SP) 被分类为骨的孤独性等离子细胞瘤 (SBP) 或外骨髓性等离子细胞瘤.
- SBP的预后比外骨髓性SP更糟糕,大约50%的患者在3-5年内发展为多发性骨髓瘤 (MM).
研究的目的:
- 追溯评估被诊断患有SBP的患者的治疗和结果.
- 评估SBP向MM的进展速度,并确定潜在的管理策略.
主要方法:
- 在2008年至2021年期间治疗的24名SBP患者的回顾性分析.
- 收集的数据包括患者人口统计,瘤部位,M蛋白检测,骨髓参与,治疗方式和随访结果.
主要成果:
- 轴骨和股骨是最常见的SBP部位.
- 38%的患者在67.2个月的中位随访期内发展为MM.
- 在5年和10年无进展生存率分别为67.3%和37.4%.
结论:
- SBP的进展率很高,可以发展为多发性骨髓瘤.
- 在SBP的管理中应考虑辅助化疗,以潜在地改善结果.
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