PAP对OSA肠道微生物群的影响:一项试点研究
Joshua M Bock1, Stephen Johnson2, Purna C Kashyap3
1Department of Cardiovascular Medicine, Mayo Clinic, 200 First St. SW Rochester, MN, 55905, United States.
Sleep medicine
|April 10, 2024
概括
在一项小型研究中,阻塞性睡眠呼吸暂停 (OSA) 的积极气道压力 (PAP) 治疗没有显著改变肠道微生物多样性. 需要进一步的研究来探索改善OSA患者肠道健康的干预措施.
科学领域:
- 微生物组研究的研究.
- 睡眠的药物 睡眠的药物
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物影响宿主健康.
- 阻塞性睡眠呼吸暂停 (OSA) 与肠道失调和增加非传染性疾病风险有关.
- 阳性气道压力 (PAP) 治疗是一种常见的OSA治疗方法.
研究的目的:
- 调查PAP疗法是否能改善中度至重度OSA患者的肠道微生物多样性.
- 在PAP治疗两个月后,评估肠道微生物α和β多样性的变化.
主要方法:
- 八名中度至重度OSA患者在PAP治疗两个月之前和之后提供了便样本.
- 分析了肠道微生物多样性,使用香农,观察和逆-辛普森指数来分析α多样性.
- 用Bray-Curtis,Jaccard和各种UniFrac指标评估了贝塔多样性.
主要成果:
- 香农多样性指数呈现上升趋势 (p=0.08),但没有达到统计学意义.
- 没有观察到观察或逆辛普森α多样性指数的显著变化.
- 没有发现β多样性或肠道分类体的差异丰度的显著变化.
结论:
- 在OSA患者中,PAP治疗可能无法有效逆转或抵消肠道失调.
- 针对肠道微生物健康的额外干预措施可能对OSA患者有益.
- 探索肠道健康的辅助疗法可以降低OSA患者的非传染性疾病风险.
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