症状集群对乳腺癌患者内分泌治疗的坚持的影响
Sommer Agnew1, Megan Crawford1, Iain MacPherson2
1University of Strathclyde, 16 Richmond St, Glasgow, G1 1XQ, Scotland, UK.
Breast (Edinburgh, Scotland)
|April 10, 2024
概括
高症状负担,特别是失眠,显著影响乳腺癌患者对内分泌治疗的坚持. 解决这些副作用对于改善药物服药和患者治疗结果至关重要.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 患者坚持的研究研究.
背景情况:
- 内分泌疗法对于乳腺癌复发和死亡率降低至关重要.
- 治疗的副作用经常阻碍药物坚持.
- 之前的研究没有确切地指出预测不坚持的特定副作用.
研究的目的:
- 调查症状集群对乳腺癌患者在内分泌治疗中自我报告的坚持的影响.
- 识别常见的症状及其与坚持行为之间的关系.
主要方法:
- 一项针对使用内分泌治疗的1051名乳腺癌患者的横截面在线调查.
- 评估自我报告的坚持和常见症状 (失眠,抑郁,焦虑,疲劳,肌肉骨,血管运动).
- K-意味着集群分析以识别症状集群.
主要成果:
- 非故意的不遵守 (50.8%) 比故意的不遵守 (31.01%) 更为普遍.
- 失眠是最普遍和麻烦的症状 (73.83%可能是失眠障碍).
- 一个"低症状"集群与更高的坚持率有显著的关联.
结论:
- 观察到高比例的不坚持,与整体严重症状有很强的联系.
- 临床医生必须主动讨论副作用作为坚持障碍.
- 未来针对中心症状的干预措施可以通过减少整体副作用负担来改善坚持.
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