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通过正子发射断层扫描来追踪细菌衍生的特定部位免疫调节剂的命运

Alexia Kirby¹, Mojmír Suchý², Daniel Duan³

¹Department of Biology, University of Ottawa, Ottawa, ON, Canada; University of Ottawa Heart Institute, Ottawa, ON, Canada.

Nuclear medicine and biology

|April 10, 2024

概括

局部特异性免疫调节剂 (SSI) 在小鼠中显示有针对性的器官贩运. 放射性标记的QBKPN和QBECO显示出不同的生物分布模式,在注射部位观察到免疫细胞透.

科学领域:

免疫学免疫学免疫学
药理学药理学是指药理学的学科.
生物医学成像技术生物医学成像技术

背景情况:

局部特异性免疫调节剂 (SSI) 是从非活化细菌中获得的新型治疗药物.
SSI的目的是调节目标器官中的先天免疫系统.
QBECO (向肠道) 和QBKPN (向肺部) 是临床开发中的SSI,用于各种疾病.

研究的目的:

描述肠道向性 (QBECO) 和肺部向性 (QBKPN) SSI 的体内贩运和生物分布.
了解在注射部位的免疫细胞透模式.

主要方法:

特定部位的免疫调节剂 (QBECO和QBKPN) 用89Zr进行放射标记.
在健康小鼠体内进行皮下注射,随后进行为期8天的纵向PET成像.
针对免疫细胞透的注射部位组织的免疫组织学分析.

主要成果:

观察到差异性的生物分布,与特定地点的向一致.
QBKPN被贩运到宫淋巴结 (肺部附近);QBECO留在腹部,被贩运到 inguinal 淋巴结 (胃肠道附近).
中性粒细胞透到两个SSI的注射部位;巨细胞透到只有QBKPN的注射部位.

结论:

放射性标记和PET成像使SSI生物分布和贩运的体内追踪成为可能.
SSI生物分布是有机的,受源细菌的影响.
涉及中性粒细胞和巨细胞的淋巴运输介导了从注射到目标部位的贩运.

关键词:

(89) 在Zrrr.生物分布生物分布免疫调节是一种免疫调节.在PET成像中使用PET成像.

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