伊朗人口中的直肠癌存活率和预后因素:一项回顾性队列研究
Seyed Kazem Mirinezhad1, Mostafa Akbarzadeh-Khiavi1, Farshad Seyednejad2
1Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer treatment and research communications
|April 10, 2024
概括
结直肠癌的生存率很低,5年生存率为47%. 晚期,转移和70岁以上的年龄显著增加了直肠癌患者的死亡风险.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 直肠癌 (RC) 是全球主要的健康问题,导致严重的发病率和死亡率.
- 研究RC患者的生存率和影响因素对于改善结果至关重要.
研究的目的:
- 为了确定直肠癌患者的生存率.
- 确定影响直肠癌存活率的人口,瘤和治疗相关因素.
主要方法:
- 对593名直肠癌患者病历进行了回顾性分析.
- 使用生命表方法估计的生存率;通过日志等级测试对子组进行比较.
- 考克斯回归分析用于确定独立的预后因素.
主要成果:
- 总体而言,1年,3年,5年和10年的生存率分别为85%,59%,47%和36%.
- 确定的显著预后因素包括年龄,教育,症状和癌症阶段.
- 先进的区域阶段 (HR=1.54),转移 (HR=3.73),年龄>70 (HR=1.65) 与增加的死亡风险有关.
结论:
- 观察到的直肠癌的预后令人担忧,强调需要进行干预.
- 症状发作和诊断之间的显著延迟导致结果不佳.
- 迫切需要制定改善直肠癌患者生存率的策略.
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