动脉瘤下关节出血病例死亡率中的性别差异:系统性审查
Aleksanteri Asikainen1, Miikka Korja2, Jaakko Kaprio3
1Department of Neurosurgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland, aleksanteri.asikainen@helsinki.fi.
Neuroepidemiology
|April 10, 2024
概括
动脉瘤下关节出血 (SAH) 在女性中更常见,但这项研究没有发现性别之间病例死亡率 (CFR) 的差异. 需要未来的研究来证实这些关于SAH死亡率的发现.
科学领域:
- 神经学 神经学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 动脉瘤下关节出血 (SAH) 在女性中比男性的发病率更高.
- 关于SAH病例死亡率 (CFRs) 的基于性别差异的现有数据仍然没有确定性.
- 这项研究系统地审查了性别和SAH CFRs之间的关系.
研究的目的:
- 系统地审查和分析1个月的SAH CFR中性别差异的基于人口的研究.
- 为了确定女性和男性是否有不同的死亡风险在动脉瘤下arachnoid出血后.
主要方法:
- 在PubMed,Scopus和Cochrane数据库进行系统的文献搜索.
- 包括基于人群的研究报告1个月SAH CFR分层按性别.
- 随机效应元分析以计算性别之间的SAH死亡相对风险比率 (RRs).
主要成果:
- 包括33个研究队列,包括53,141个SAH病例;60.3%是女性.
- 聚合分析显示,女性 (35.5%) 和男性 (35.0%) 的1个月CFR没有显著差异 (RR = 0.99 [95%CI:0.93-1.05]).
- 所有纳入的研究都被评为质量低,原因是混,样本大小和诊断准确性问题.
结论:
- 在男性和女性之间,SAH病例死亡率似乎没有显著差异.
- 女性中SAH发病率较高并不意味着死亡风险更高.
- 需要进一步的高质量研究,专门用于调查SAH CFR中的性别差异.
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