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索马托斯塔丁内部神经元控制皮质网络中发育失同的时间

Laura Mòdol¹, Monika Moissidis¹, Martijn Selten¹

¹Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK; MRC Centre for Neurodevelopmental Disorders, King's College London, London, UK.

|April 10, 2024

概括

研究人员发现,体静止素表达 (SST+) 内神经元控制在发育过程中从同步到脱相关的大脑活动的切换. 调节SST+细胞会影响这种关键的过渡和其他内部神经元的成熟.

科学领域:

神经科学是一个神经科学.
发展生物学发展生物学
计算神经科学是一种神经科学.

背景情况:

同步的神经元活动是发育中的大脑的特征.
在出生后的第二周内,皮质活动脱节,导致感官集成的稀疏模式.
在这种发育过渡过程中,特定内神经元的作用仍然不清楚.

研究的目的:

为了确定负责从同步到脱相关网络活动转移的内部神经元在发育中的小鼠皮质.
了解这些内部神经元如何调节这一关键的发育过程.

主要方法:

在小鼠体内纵向两光子成像.
在同步到不相关活动开关之前的期间进行观察.
调节体静止素表达 (SST+) 内神经元活动.

主要成果:

索马托斯坦素表达性 (SST+) 内神经元被确定为同步到脱相关活动开关的关键调节器.
调节SST+细胞活动加速或延迟皮质网络的脱相关性.
这一过程涉及调节表达帕瓦胺 (PV+) 内神经元的成熟.

结论:

SST+内部神经元对于协调皮质网络活动的发育过渡至关重要.
SST+细胞将传感输入与局部电路连接起来,控制神经动力学,并将其他内部神经元集成到正在发展的电路中.

关键词:

对于GABA来说,这是一个很好的选择.桶皮质皮质桶皮质大脑皮层大脑皮层内部神经元内部神经元内部神经元产后发展产后发展化是一种散射的过程.自发性活动是一种自发性的活动.同步活动的同步活动.

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