来自CT的脊椎骨矿物质密度是预测COVID-19结果的有用生物标志物
Shuhei Azekawa1, Tomoki Maetani2, Shotaro Chubachi1
1Division of Pulmonary Medicine, Department of Medicine, Keio University, School of Medicine, Tokyo, Japan.
Bone
|April 10, 2024
概括
通过CT扫描测量的低骨矿物质密度 (BMD) 与COVID-19患者的更差结果有关. 这项研究发现,低BMD预测严重疾病,并且在住院患者中可能随着时间的推移而降低.
科学领域:
- 放射学 放射学是一门学科.
- 骨质疏松症研究 骨质疏松症研究
- 传染病流行病学 传染病流行病学
背景情况:
- 低骨矿物质密度 (BMD),以低计算断层扫描 (CT) 霍恩斯菲尔德单位表示,是已知的骨质疏松症标志物.
- 对于2019年冠状病毒病 (COVID-19) 严重程度的低BMD的预后值尚不清楚.
研究的目的:
- 研究日本COVID-19患者的BMD和临床结果之间的关联.
- 为了评估BMD是否预测COVID-19感染期间的关键结果和随时间变化.
主要方法:
- 一个多中心回顾性队列研究1132名COVID-19住院患者 (2020年2月至2022年9月).
- 从胸椎脊椎的CT值计算出BMD.
- 在入院和感染后3个月内对骨质量进行比较分析.
主要成果:
- 与高BMD患者相比,低BMD患者的临界结局比例更高.
- 低的BMD独立地与关键的COVID-19结果相关,以及慢性脏病和糖尿病.
- 在住院期间需要氧气的患者在感染后3个月显示 BMD 降低.
结论:
- 低BMD可能成为严重COVID-19疾病发病的预测因素.
- 在严重的COVID-19病例中,BMD可能会下降,因此需要进一步调查其对后果的影响.
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