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有毒金属和儿科临床免疫功能障碍:对流行病学证据的系统审查

Marina Oktapodas Feiler¹, Erin R Kulick², Krystin Sinclair²

¹Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, United States of America; Department of Epidemiology and Biostatistics, College of Public Health, Temple University, United States of America.

The Science of the total environment

|April 10, 2024

概括

暴露于和等有毒金属的儿童表现出免疫功能障碍的迹象. 本综述综合了关于重金属对儿童影响的研究.

科学领域:

环境健康环境健康
儿科免疫学儿科免疫学
毒理学毒理学毒理学

背景情况:

儿童因接触有毒金属而面临重大风险,导致免疫系统脆弱.
关于有毒金属和儿科免疫功能障碍的现有研究显示出不一致.
需要对文献进行批判性评估,以澄清这些关联.

研究的目的:

系统地审查和评估有关有毒金属 (,,,,) 与儿科免疫功能障碍之间的联系的现有文献.
识别当前研究中的不一致性和知识差距.
提供对有毒金属对儿童免疫健康的影响的全面概述.

主要方法:

在2024年2月,在七个主要数据库 (PubMed,Embase,CINAHL,Web of Science,ProQuest公共卫生,ProQuest环境科学) 进行了系统的文献搜索.
研究按标题,摘要和全文进行了选,遵循PRISMA指南,使用Rayaan软件进行盲目独立审查.
纳入标准侧重于研究有毒金属和儿科免疫健康结果的原始流行病学研究.

主要成果:

最初的搜索产生了7906个结果,删除了2456个重复结果.
总共有79项研究被纳入最终审查.
这些研究评估了暴露于有毒金属和儿科免疫失调的各种指标之间的关联.

结论:

目前的证据表明,有毒金属暴露与儿童免疫失调之间存在联系.
鉴于传染病和过敏性疾病的增加,了解这些影响至关重要.
进一步的研究是必要的,以澄清早期的金属暴露如何影响免疫反应,感染易感性和疫苗疗效.

关键词:

亚是一种.是的组成部分.孩子孩子孩子孩子过敏症是一种过敏症.免疫抑制是一种免疫抑制.领导领导领导领导领导水星水星水星水星水星

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