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瘦与非瘦MASLD中的心血管发病率和死亡率:全面的元分析

Nso Nso¹, Damla Mergen², Mashaal Ikram¹

¹Division of cardiovascular disease, University of Chicago (Endearvor Health), IL, USA.

Current problems in cardiology

|April 10, 2024

概括

瘦个体与代谢功能障碍相关的脂肪性肝病 (MASLD) 具有较高的心血管死亡风险,尽管心脏代谢概况总体上更健康. 这一发现凸显了这一患者群体的一个关键问题.

科学领域:

心脏病学心脏病学
肝病学肝病学是一种肝病学.
代谢疾病代谢疾病

背景情况:

瘦身代谢功能障碍相关的脂肪性肝病 (MASLD),以较低的BMI来定义,与非瘦身MASLD相比,具有独特的预后挑战.
瘦与非瘦MASLD人群中的心血管结果需要进一步调查.

研究的目的:

为了比较患有MASLD的瘦身和非瘦身个体之间的心血管结果.
分析心血管死亡,主要心血管不良事件 (MACE) 和相关疾病的风险.

主要方法:

进行了一项元分析,汇集了来自21项研究的数据,比较了瘦身和非瘦身的MASLD队列.
为初级和二级心血管结果计算了95%置信区间 (CI) 的聚合几率比率 (OR).

主要成果:

瘦身MASLD患者 (n=7153) 与非瘦身MASLD患者 (n=23,514) 相比,心血管死亡率增加了50%.
虽然MACE和心血管疾病 (CVD) 的几率较低,但所有原因的死亡风险都较高.
瘦身 MASLD 与高血压和脂质失调的几率较低有关.

结论:

患有MASLD的瘦个体面临心血管死亡的风险明显更高.
尽管看似有利的心脏代谢特征,但死亡率高的风险强调了需要针对性心血管风险管理在瘦身的MASLD患者.

关键词:

心血管死亡率的心血管死亡率心血管方面的结果.瘦身的现象型是瘦身的现象型.进行元分析分析.与代谢功能障碍相关的脂肪性肝病 (MASLD)

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