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根据功能参数的死亡风险和死亡原因:韩国一项全国性的观察性研究
Sehyun Jung1, Soojin Lee2,3, Yaerim Kim4
1Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, Republic of Korea.
Kidney research and clinical practice
|April 10, 2024
概括
功能标志物,包括估计的膜过率 (eGFR) 和白色素尿,与增加的死亡风险有关. 降低EGFR和脏过都预测了各种原因的死亡.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 功能标志物,如EGFR和白蛋白尿,对于评估健康至关重要.
- 功能与全因死亡率之间的关联需要进一步调查.
研究的目的:
- 确定估计的淋巴膜过率 (eGFR) 和白蛋白尿与所有原因和特定原因死亡率之间的关联.
- 确定功能参数作为死亡率的独立预测指标.
主要方法:
- 在韩国使用索赔数据对超过1000万名普通健康查考生进行了查.
- 包括9,917,838名基线功能测量患者,不包括功能衰竭患者.
- 利用多变量考克斯回归分析来评估基于国际疾病分类,第10次修订编码的死亡风险.
主要成果:
- 与参考范围 (90-120mL/min/1.73m2) 相比,在EGFR<60和EGFR≥120mL/min/1.73m2的组中观察到显著更高的死亡风险.
- 由于与异常EGFR相关的心血管,癌症,感染,内分泌,呼吸和消化原因的死亡风险增加.
- 专素尿独立预测了所有EGFR范围内的更高的死亡风险,在较高的专素尿类别中风险增加.
结论:
- 再次证实了eGFR,白蛋白尿和死亡率之间的显著关联.
- 专尿和降低eGFR是死亡率的独立预测因素.
- 过 (eGFR ≥120 mL/min/1.73 m2) 也是死亡率的一个独立预测因素.
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