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Updated: Jun 28, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

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对抗剂配体与REV-ERBα结合的机制

Mohammad Homaidur Rahman1,2, Lamees Hegazy3,4

  • 1Center for Clinical Pharmacology, Washington University School of Medicine, University of Health Sciences and Pharmacy, St. Louis, MO, USA.

Scientific reports
|April 10, 2024
PubMed
概括

研究人员使用高斯加速分子动力学 (GaMD) 来绘制SR8278,REV-ERBα抗剂如何与受体结合. 这种方法有助于开发针对核激素受体的新药.

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Prediction and Validation of Gene Regulatory Elements Activated During Retinoic Acid Induced Embryonic Stem Cell Differentiation

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