相关实验视频

Updated: Jun 28, 2025

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

聚合物特性用于在颗粒上涂层药物,使用新型融颗粒技术,MALCORE®

Ryota Kimata^1,2, Naoki Yoshihara^1,2, Yuya Tomita¹

¹School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-Ku, Shizuoka, 422-8526, Japan.

AAPS PharmSciTech

|April 10, 2024

概括

研究人员探索了用于MALCORE®化颗粒的新聚合物,发现聚烯 (PVP) 有效. 这扩大了制造含药颗粒 (DCP) 的聚合物选择,并保持了一致的质量.

科学领域:

制药技术制药技术制药技术
材料科学材料科学材料科学

背景情况:

马尔科尔 (MALCORE) 是一种化颗粒技术,用于生产含药物颗粒 (DCP).
有效的聚合物选择对于MALCORE®中融粘度和颗粒性质至关重要.
氨基甲基烯酸合聚合物E (AMCE) 是迄今为止唯一使用的聚合物.

研究的目的:

为了确定用于MALCORE®化颗粒的替代聚合物.
了解聚合物对于这一过程的基本特性.

主要方法:

在酸 (SA) 溶解中研究了聚烯 (PVP) 的溶解性.
利用里叶变换红外光谱法 (FTIR) 来评估聚合物-SA相互作用.
采用相位图来确定液态的最佳混合比率和温度范围.
分析了聚合物数量和分子量对混合物粘度的影响.

主要成果:

聚烯利 (PVP) 在酸 (SA) 溶解中表现出可溶性.
FTIR证实SA和PVP之间没有化学相互作用.
阶段图确定了液体SA-PVP混合物的特定混合比率和温度范围.
融化成分的粘度受到PVP度和分子重量的直接影响.
通过MALCORE®使用PVP制造的DCP显示了与AMCE制造的DCP相似的药物特性.

结论:

聚烯 (PVP) 是一种可行的替代聚合物用于MALCORE®化颗粒.
了解聚合物特性 (溶解度,分子量) 是优化MALCORE®制造的关键.
这项研究可以加强对温度和混合比率的控制,以实现一致的DCP生产.

关键词:

含有毒品的颗粒.融化颗粒化的融化颗粒.一个相位图的相位图.聚维尼尔皮罗利多的使用.粘度粘度粘度粘度粘度

更多相关视频

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Published on: September 20, 2011

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

相关概念视频

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...