在SGLT2抑制剂与DPP4抑制剂之间比较发生的高血压
Yuta Suzuki1,2, Hidehiro Kaneko3,4, Akira Okada5
1The Department of Cardiovascular Medicine, The University of Tokyo, Tokyo, Japan.
概括
-葡萄糖携带载体2抑制剂 (SGLT2i) 可能会降低糖尿病患者患高血压的风险. 这项研究发现,与DPP4抑制剂相比,SGLT2i的使用与高血压的发病率较低有关.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 已知-葡萄糖共运输体2抑制剂 (SGLT2i) 可能降低血压 (BP).
- SGLT2i对糖尿病患者新发高血压的发生率的影响尚不清楚.
- 双基酶4抑制剂 (DPP4i) 在这个现实研究中作为比较药物类.
研究的目的:
- 调查SGLT2i使用是否降低了糖尿病患者发生高血压的风险.
- 为了比较新处方SGLT2i与DPP4i的患者之间的高血压发病率.
- 为了确定可能从SGLT2i中获益最多的子组,以预防高血压.
主要方法:
- 对糖尿病患者的大规模流行病学数据库的分析.
- 倾向性得分匹配以创建可比较的SGLT2i和DPP4i用户群.
- 主要结局是新发高血压的发生率.
主要成果:
- 在匹配后,分析了5708对SGLT2i和DPP4i用户.
- 施用SGLT2i与显著降低高血压风险相关 (HR 0.91,95% CI:0.84-0.97).
- 这种保护作用在所有灵敏度分析中是一致的,在男性,HbA1c<7.5%的患者和基线SBP≥127 mmHg的患者中观察到.
结论:
- 现实数据表明,SGLT2i在预防糖尿病患者高血压发展方面可能比DPP4i具有优势.
- 在这一群体中,SGLT2i显示出作为治疗高血压风险降低的治疗策略的潜力.
- 进一步的研究可能会阐明SGLT2i抗高血压作用背后的机制.
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