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细胞外囊泡及其对血管血动力学的影响:系统性审查
Sharon W Y Cheung1, Lawrence W Chamley1,2, Carolyn J Barrett3
1Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand.
概括
细胞外囊泡 (EVs) 损害血管扩张,增强血管收缩,影响血管健康. 在体内研究对于确认这些对心血管血液动力学影响至关重要.
科学领域:
- 心血管科学 心血管科学
- 细胞生物学 细胞生物学
- 生物医学工程 生物医学工程
背景情况:
- 细胞外囊泡 (EVs) 是关键的细胞间通讯器,参与恒温和疾病,包括心血管疾病.
- 血含有高度的循环EVs,这些EVs来自不同的细胞来源.
- 了解EV对血管血动力学的影响对于疾病研究至关重要.
研究的目的:
- 系统地审查和总结有关外源注射EV如何影响血管血液动力学的文献.
- 为了确定EV诱导的血管扩张和血管收缩变化的模式.
- 评估ex vivo发现的转化到in vivo动物模型.
主要方法:
- 系统的文献搜索对外源性EV给药和血管血液动力学研究.
- 来自电线和压力肌肉图 (ex vivo) 的数据分析.
- 在麻醉和有意识的动物模型 (体内) 进行研究的综述.
主要成果:
- 活体研究表明,来自血液/血管细胞的EVs会损害血管扩张.
- 由心血管疾病和代谢综合征 (例如糖尿病) 引起的EV改变了血管反应 (血管扩张受损,血管收缩增加).
- 在有意识动物的体内数据并不总是与体外发现一致.
结论:
- 外源EV显著影响血管度,影响因EV来源和疾病背景而异.
- 外体和体内结果之间的差异凸显了需要更全面的体内研究.
- 进一步的体内研究对于了解EVs对血管血液动力学的综合作用至关重要.
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