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Updated: Jun 28, 2025

The Citrobacter rodentium Mouse Model: Studying Pathogen and Host Contributions to Infectious Colitis
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被C. rodentium准的远端结肠细胞招募T细胞帮助进行屏障防御

Carlene L Zindl1, C Garrett Wilson2, Awalpreet S Chadha3

  • 1Department of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. carlenezindl@uabmc.edu.

Nature
|April 10, 2024
PubMed
概括

互白素22 (IL-22) 保护肠道屏障. 研究人员发现,特定的结肠细胞需要T细胞衍生的IL-22和主要基因相容性复合物II类 (MHCII) 的表达,以防止病原体入侵.

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The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
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