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Updated: Jun 28, 2025

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
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Published on: December 17, 2019

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FOXO1是CAR T细胞内内存编程的主调节器

Alexander E Doan1, Katherine P Mueller2,3,4, Andy Y Chen5,6,7

  • 1Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Nature
|April 10, 2024
PubMed
概括

转录因子FOXO1促进记忆,并防止化学抗原受体 (CAR) T细胞的衰竭. 过度表达FOXO1增强了CAR T细胞的持久性和抗瘤活性,改善了癌症免疫疗法的结果.

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