门诊护理中痴呆症患者的潜在不适当处方:一个横截面观察性研究
Nahla A Alageel1,2, Carmel M Hughes1, Monira Alwhaibi2
1Primary Care Research Group, School of Pharmacy, Medical Biology Centre, Queen's University Belfast, 97 Lisburn Road, BT9 7BL, Belfast, UK.
BMC geriatrics
|April 10, 2024
概括
潜在不适当的处方 (PIP) 影响了沙特阿拉伯61%的痴呆症患者,多药是显著的风险因素. 这突出了对优化药物管理在这个群体的关键需求.
科学领域:
- 老年医学 老年医学
- 临床药房 临床药房
- 公共卫生 公共卫生
背景情况:
- 潜在不适当的处方 (PIP) 在痴呆症患者 (PwD) 中很普遍,与住院治疗和死亡率等不良结果有关.
- 关于在沙特阿拉伯特定的PWD处方适宜性的数据有限.
- 本研究通过检查沙特阿拉伯的门诊PWD中的PIP患病率和相关因素来解决这一差距.
研究的目的:
- 估计痴呆症患者 (PwD) 中潜在不适当处方 (PIP) 的患病率.
- 调查PIP与患者特征之间的关联,包括多药性,年龄和性别.
- 为沙特阿拉伯的门诊护理机构提供关于PWD药物适宜性的数据.
主要方法:
- 在沙特阿拉伯 (2019-2021) 的一家三级医院对287名PWD (≥65岁) 的回顾性,横截面分析.
- 使用老年人潜在不适当处方 (STOPP) 标准的选工具评估处方适当性.
- 后勤回归用于确定PIP,多药,年龄和性别之间的关联.
主要成果:
- 在61.0%的PWD中发现PIP的高患病率.
- 常见的PIP实例包括长时间使用药物 (31.4%),未指示处方 (27.2%) 和特定药物组合 (例如,PPI>8周,26.0%).
- 多药性 (82.6%的患者) 与PIP有很强的关联 (调整后OR 24.1).
结论:
- 在沙特阿拉伯,潜在不适当的处方 (PIP) 在痴呆症患者 (PwD) 中非常普遍.
- 多药性是一个重要的风险因素,在这个人群中与PIP密切相关.
- 建议进一步研究利益相关者对药物管理的看法,以优化PWD的护理.
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