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多焦点瞳孔周长度和视网膜神经纤维层之间的结构功能关系在青光眼中

Corinne F Carle¹, Allan Y H Chain², Maria Kolic³

¹Neuroscience, The John Curtin School of Medical Research, Australian National University, Building 131 Garran Road, Canberra ACT, 2601, Australia. corinne.carle@anu.edu.au.

BMC ophthalmology

|April 10, 2024

概括

多焦点瞳孔图形客观周边测量 (mfPOP) 和标准自动周边测量 (SAP) 在青光眼中显示出类似的结构功能关系. mfPOP与视网膜神经纤维层厚度相关,特别是在晚期疾病中.

科学领域:

眼科医生眼科眼科
神经科学是一个神经科学.
医疗成像医学成像

背景情况:

多焦点瞳孔图形客观周边测量 (mfPOP) 是一种新的绿眼的功能评估工具.
据认为,mfPOP反应涉及通过外层皮质的主要视觉通路,与黑色素反应不同.

研究的目的:

为了研究mfPOP检测到的围状视网膜神经纤维层 (pRNFL) 厚度和眼性视野变化之间的相关性.
将mfPOP与标准自动周边测量 (SAP) 进行比较,以评估青光眼中结构功能关系.

主要方法:

25名青光眼患者和24名正常受试者接受了SAP,3种mfPOP变体和光学连贯性断层扫描 (OCT).
使用加权的弧形集群,pRNFL厚度和视野灵敏度是相关的.
结构-功能相关系数 (r) 为pRNFL部门和局部视野敏感度计算.

主要成果:

在pRNFL厚度和mfPOP LumBal之间,最强的相关性 (r=0.93) 是严重损伤眼睛的上超时盘部门 (SAP MD < -12 dB).
总体相关性在SAP (r=0.54) 和mfPOP (r=0.55) 两种严重疾病中最强.
在较轻的疾病中,SAP显示出更高的相关性,而mfPOP在更晚期的疾病和正常人中显示出更高的相关性.

结论:

无论mfPOP还是SAP都在青光眼中表现出类似的结构功能关系,在严重受损眼睛的下鼻野中相关性最强.
这些发现支持mfPOP在通过皮层途径评估眼性视野缺陷方面的作用.

关键词:

眼光障碍眼光障碍眼光障碍眼光障碍目标周长线的目标周长线.视网膜神经纤维层是一种神经纤维层.结构/功能结构/功能

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