C反应蛋白与冠状动脉化之间的关联:系统性审查和元分析
Amirhossein Tajani1, Masoumeh Sadeghi2, Navid Omidkhoda1
1Department of Clinical Pharmacy, School of Pharmacy, Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
BMC cardiovascular disorders
|April 10, 2024
概括
C-反应蛋白 (CRP) 水平不能预测冠状动脉化 (CAC) 的发生率或进展. 这次元分析发现CRP和CAC之间没有显著的关联,这挑战了其作为预后标记物的使用.
科学领域:
- 心血管医学 心血管医学
- 生物标志物 生物标志物
- 流行病学 流行病学
背景情况:
- 冠状动脉化 (CAC) 是冠状动脉样硬化的关键指标.
- 讨论了C-反应蛋白 (CRP) 水平与CAC发育/进展之间的联系.
研究的目的:
- 系统地审查和元分析调查CRP和CAC之间的关联的观察性研究.
- 确定CRP是否是CAC发病率和进展的可靠预后标志物.
主要方法:
- 在PubMed,Embase,Web of Science和Scopus进行了全面的搜索,直到2023年10月.
- 使用纽卡斯尔-太华尺度 (NOS) 评估方法质量.
- 随机效应元分析被用于计算聚合几率比率 (OR) 和95%置信区间.
主要成果:
- 该审查包括42个横截面和9个队列研究.
- 对12项横截面研究的元分析表明,CAC和CRP之间没有显著的关联 (OR:1.03;95%CI:1.00,1.06).
- 对3项队列研究的元分析也发现了与低异质性的无意义关联 (OR:1.05;95%CI:0.95,1.15) .
结论:
- 升高的CRP水平不是预测冠状动脉化发生率或进展的可靠预后标记.
- 目前的证据不支持使用CRP来对CAC进行风险分层.
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