出生窒息和发烧发作之间对自闭症谱系障碍的附加相互作用:基于人口的研究
Yi Mao1, Xindi Lin1, Yuhan Wu1
1Department of Developmental and Behavioral Pediatrics, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Molecular autism
|April 10, 2024
概括
出生窒息 (BA) 和发烧性 (FS) 与自闭症谱系障碍 (ASD) 风险增加有关. 它们的联合存在显著地提高了自闭症患病率,超过了单个因素,突出了附加性相互作用.
科学领域:
- 神经发育障碍 神经发育障碍
- 儿科卫生健康 儿科卫生健康
- 流行病学 流行病学
背景情况:
- 自闭症谱系障碍 (ASD) 显著影响社会融合.
- 以前的研究表明,出生窒息 (BA) 和发烧性 (FS) 之间存在单独的联系,ASD患病率更高.
- BA和FS对ASD风险的相互作用影响仍未得到充分研究.
研究的目的:
- 在自闭症谱系障碍的背景下,探索出生窒息和发烧的互动效应.
- 量化BA和FS对ASD的综合风险.
主要方法:
- 使用多阶段分层集群采样方法,招募了上海3至12岁的84,934名儿童.
- 使用后勤回归模型来估计相互作用效应,控制共变量.
- 计算了可归因比例 (AP),因相互作用而导致的相对过度风险 (RERI),协同作用指数 (SI) 和乘法尺度相互作用.
主要成果:
- 在74,251名儿童中,有192名 (0.26%) 被诊断为ASD.
- 针对ASD的调整后几率比为单独BA的3.82,单独FS的3.06,并显著更高,为共患BA和FS的21.18.
- 在BA和FS之间观察到统计学上显著的添加相互作用 (P < 0.001),而乘数相互作用并不显著 (P > 0.05).
结论:
- BA和FS都与ASD有显著的关联.
- BA和FS的共存表明了统计学上显著的附加相互作用,大大增加了超出单个风险的总和的ASD患病率.
- 需要进一步研究更大的样本大小和详细的分类来证实这些发现并探索潜在的神经机制.
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