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在血友病患者的脚关节结构变化和疼痛感知

Alexander Schmidt¹, Michael Sigl-Kraetzig², Heinrich Richter³

¹Department of Sports Medicine, University of Wuppertal, Wuppertal, Germany.

Haemophilia : the official journal of the World Federation of Hemophilia

|April 11, 2024

概括

血友病 (PwH) 患者的慢性疼痛与脚关节损伤和活动有关. 即使是轻微的突炎也会影响疼痛,而严重的退化最强烈地使疼痛感知敏感.

科学领域:

整形外科整形外科整形外科
类风湿病学类风湿病学
疼痛医学医学疼痛医学

背景情况:

患有血友病 (PwH) 的患者经历慢性疼痛,通常是由于经常出血引起的关节损伤造成的.
脚关节并发症是PwH患者疼痛和生活质量下降的重要来源.

研究的目的:

研究血友病患者的脚关节结构变化和疼痛感知之间的相关性.
要区分关节活动 (关节炎) 与关节损伤 (软骨/骨退化) 对疼痛敏感性的影响.

主要方法:

使用HEAD-US协议进行的超声检查 (US) 评估了79名PwH和57名对照组的关节活动和损伤.
使用压力疼痛值 (PPT) 测量疼痛敏感度.
参与者根据美国活动和损害的发现被分为子组.

主要成果:

与对照组相比,PwH表现出明显更高的关节活动和关节损伤 (p ≤.001).
结构变化,包括突炎和退化,与增加疼痛敏感性直接相关 (p ≤.001).
严重的关节退行显示出与敏感疼痛状态的最强有力的关联,而最初的退行性变化的影响较小.

结论:

在普华永道,关节活动,关节损伤和疼痛感知之间存在明显的关系.
即使是轻微的关节炎 (关节炎) 也可以影响疼痛感知,而不一定会随着炎症水平的提高而加剧.
渐进性关节损伤显著导致血友病患者疼痛敏感度升高.

关键词:

脚脚在脚上血友性关节炎是一种血友性关节病.疼痛疼痛疼痛疼痛压力疼痛的门值.综合性炎症综合性炎症超声波超声波是指超声波的使用.

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