乙异硫酸的营养来源和抗癌潜力:分子机制和治疗见解
Shahira M Ezzat1,2, Rana M Merghany3, Passent M Abdel Baki1
1Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt.
Molecular nutrition & food research
|April 11, 2024
概括
乙异硫酸 (PEITC),在十字花蔬菜中发现,通过诱导亡和抑制癌细胞生长,显示出作为抗癌剂的希望. 需要进一步的研究来优化其在癌症治疗中的使用.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乙异硫酸 (PEITC) 是一种来自十字植物蔬菜的天然化合物,具有已记录的抗癌潜力.
- 现有研究强调了PEITC在多种癌症类型中的有效性,包括乳腺癌,前列腺癌,肺癌,结肠癌和胰腺癌.
研究的目的:
- 审查和综合目前关于PEITC抗癌性质的研究.
- 阐明PEITC发挥抗癌作用的具体作用机制.
- 评估PEITC作为癌症治疗中的治疗剂的潜力.
主要方法:
- 关于PEITC和癌症的临床前和临床研究的文献综述.
- 分析PEITC对关键癌症特征的影响:细胞亡,扩散,血管新生和转移.
- 检查PEITC对关键细胞信号通路 (NF-κB,Akt,MAPK) 的影响.
主要成果:
- 通过诱导细胞亡 (编程细胞死亡),PEITC显示出抗癌活性.
- 它有效地抑制癌细胞的增殖,血管新生和转移.
- PEITC针对和调节关键的与癌症相关的信号通路,包括NF-κB,Akt和MAPK.
结论:
- 由于其多方面的作用机制,PEITC作为各种癌症的治疗剂具有显著的潜力.
- 进一步研究最佳剂量,生物可用性和安全性概况对于临床应用至关重要.
- 基于PEITC的癌症疗法需要额外的研究才能获得有效和安全的临床开发.
更多相关视频
12:00Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
19.1K
13:18Network Pharmacology Prediction and Experimental Validation of Trichosanthes-Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma
Published on: March 3, 2023
1.2K
相关概念视频
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:34Inhibition of Cdk Activity
4.7K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.7K
01:05Cancer-Critical Genes II: Tumor Suppressor Genes
7.4K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
7.4K
01:27Cytotoxic T Cells-mediated Immune Response
904
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
904
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K