松树皮提取物及其化合物的对特定致病和益生菌细菌菌株的影响
Teresa Sánchez-Moya1, Rubén López-Nicolás1, Patricia Peso-Echarri1
1Department of Food Science and Nutrition, Faculty of Veterinary Sciences, Regional Campus of International Excellence Campus Mare Nostrum, University of Murcia, Murcia, Spain.
Frontiers in nutrition
|April 11, 2024
概括
法国海上松树皮提取物 (PBE) 和其化合物显示出对肠道病原体的抗菌活性. 这些化合物可能有助于管理炎症性肠道疾病 (IBD),如性结肠炎和克罗恩病.
科学领域:
- 胃肠病学 胃肠病学
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),是由于肠道失生症和对肠道微生物群的耐受性丧失造成的.
- 植物衍生的化合物正在研究它们对调节肠道炎症和恢复平衡的潜力.
研究的目的:
- 评估法国海上松树皮提取物 (PBE) 和其成分对病原细菌的体外抗菌活性.
- 评估PBE和化合物对肠道微生物群组成调节的影响.
主要方法:
- 在实验室中评估PBE和特定的化合物 (咖啡酸,酸,酸,酸,酸,taxifolin) 对特定病原体的抗微生物活性.
- 评估这些化合物对有益益生菌生长的影响.
主要成果:
- PBE和化合物在1.25 mg/mL时表现出显著的病原体生长抑制.
- 特定化合物显示有针对性的活性:咖啡酸和酸对抗E. sakazakii和E. faecalis;出租车素对抗Listeria sp. (~98%的降低);酸对抗金黄色菌.
- PBE显示出对大肠杆菌O157:H7.7的强烈抑制. PBE,咖啡酸和基酸支持益生菌的生长,而高度的出租车folin可能会损害有益的微生物群.
结论:
- 法国海上松树皮提取物及其成分具有适用于胃肠道健康的抗菌性质.
- 这些发现表明,PBE及其组件在管理IBD相关的失生症和炎症方面具有潜在的治疗应用.
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