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使用单细胞RNA测序阐明辐射诱导心脏巨细胞异质性和功能的变化

Chunxiang Cao1,2, Ran Wu1,2, Shubei Wang1,2

  • 1Department of Radiation Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in immunology
|April 11, 2024
PubMed
概括

辐射暴露会暂时损害心脏功能并改变心脏巨细胞. 这项研究揭示了不同的巨细胞种群,包括老化相关和干扰素相关的类型,在辐射诱导的心脏损伤的早期恢复期间.

关键词:
造成的DNA损伤是DNA损伤.心脏损伤心脏损伤的伤害干扰子干扰子干扰子辐射辐射辐射的辐射.巨细胞是一个巨细胞.线粒体功能障碍 线粒体功能障碍衰老是一种老化.一个单细胞RNA测序.

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RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...