功能性便秘的中年和老年患者白质网络属性的异常
Hou Xueyan1,2, Ai Qi1,3, Song Chunming1
1Department of Radiology, Xinhua Hospital Affiliated to Dalian University, Dalian, Liaoning, China.
Frontiers in neurology
|April 11, 2024
概括
功能性便秘 (FC) 的中年和老年患者表现出改变的白质网络拓. 这些大脑变化,特别是在ORBmid.R区域,与生活质量相关,表明潜在的诊断标记.
科学领域:
- 神经成像是一种神经成像.
- 医学科学 医学科学 医学科学
- 胃肠病学 胃肠病学
背景情况:
- 功能性便秘 (FC) 是一种常见的疾病,影响中年和老年人.
- 了解FC的神经生物学基础对于开发有效治疗方法至关重要.
研究的目的:
- 用扩散张力成像 (DTI) 来研究中年和老年CF患者白质网络的拓性质.
- 评估观察到的白质网络变化与FC患者的临床数据之间的相关性.
主要方法:
- 招募了29名FC患者和31名健康对照 (HC).
- 收集了磁共振成像和临床数据.
- 使用确定性纤维跟踪,图形理论和部分相关性分析分析了白质网络变化.
主要成果:
- FC患者在几个大脑区域,包括额叶和海马体,表现出节点聚类系数和局部效率的降低.
- 在海马和杏仁体等其他区域观察到节点局部效率和聚类系数的增加.
- 右轨道中额头 (ORBmid.R) 的节点效率与"患者对便秘的评估"质量调查问卷 (PAC-QoL) 的得分正相关.
结论:
- 中年和老年FC患者在与边缘系统,补充运动皮质和默认模式网络相关的大脑区域中表现出明显的白质网络特性.
- ORBmid.R节点效率与PAC-QoL之间的相关性表明,FC可能涉及该区域的异常内脏感官运动处理.
- 这些发现为FC提供了潜在的成像生物标志物和治疗点.
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