查蒂斯加尔邦巴斯塔尔区的年轻成年人中日本脑炎的爆发:一项简短的观察性研究
Jaishriram Rathored1, Rani Soni2, Sandesh Shende1
1Department of School of Allied Sciences, Central Research Laboratory and Molecular Diagnostics, Datta Meghe Institute of Higher Education & Research, Wardha, IND.
Cureus
|April 11, 2024
概括
日本脑炎病毒 (JEV) 在印度巴斯塔尔的儿童中引起了急性脑炎综合征 (AES) 爆发. 这项研究确定了JEV为病因,强调了改善儿童AES病例的诊断和护理的需要.
科学领域:
- 传染性疾病 传染性疾病
- 病毒学 病毒学
- 流行病学 流行病学
背景情况:
- 从2018年8月到2019年8月,在印度查蒂斯加尔邦巴斯塔尔部落地区观察到急性脑炎综合征 (AES) 爆发,特别是在儿童中.
- 他们注意到巴斯塔尔地区的环境因素,包括田,高猪对牛的比率,Culex vishnui蚊子的存在,低社会经济地位和有限的健康意识.
研究的目的:
- 调查报告的AES病例背后的潜在病毒病因,表明正在进行的疫情.
- 为了确定在巴斯塔尔地区负责AES的特定病毒病原体.
主要方法:
- 进行了临床调查和血清学调查,以确定AES的病毒原因.
- 在日本脑炎病毒 (JEV) 检测中心分析了发烧患者的128个样本.
- 使用JEV IgM ELISA测试来确认最近的JEV感染.
主要成果:
- 在213名患者中,71人呈现了AES. JEV IgM ELISA证实了18例发生了JEV阳性病例,表明最近的感染.
- 绝大多数 (94.44%) 的JEV阳性患者是16岁以下的儿童,这凸显了他们的脆弱性.
- 虽然61.11%的JEV阳性病例是男性,但性别差异在统计上并不显著 (p=0.18).
结论:
- 这项研究证实日本脑炎病毒 (JEV) 是巴斯塔尔地区儿童AES的重要原因.
- 强调需要准确的病因诊断和基于证据的AES管理.
- 了解诊断算法性能是改善AES患者护理的关键.
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